Hummingbird Diagnostics GmbH

Forschungsschwerpunkte: Development of innovative non-invasive Biomarkers

Services: CENTER OF EXCELLENCE FOR CIRCULATING BIOMARKERS YOUR MOLECULAR CRO FOR CLINICAL BIOMARKER PROGRAMS

The Comprehensive Biomarker Center GMBH (CBC) successfully operates as Center of Excellence for circulating Biomarkers to overcome limitations in current Disease Monitoring and Molecular Diagnostics. Offering tailored solutions in Discovery, Development, and Validation of novel non-invasive RNA-, DNA- & Protein- Biomarkers for Diagnostics and Companion Diagnostics, the CBC strives to facilitate Precision Medicine for Personalized Healthcare. Experienced with more than 6000 clinical body fluid samples from clinical trials and academic projects, the CBC operates standardized processes (on track to ISO 17025 certification) and utilizes a proprietary bioinformatics pipeline for multivariate Biomarker signature development & validation. The CBC provides highly efficient first-in-class comprehensive solutions from molecular sample preparation to validated non-invasive biomarkers.

RNA/DNA EXTRACTION • Whole blood (PAXgene), Serum, Plasma, Urine, CSF, Exosomes, FFPE

DISCOVERY • Microarray Services Agilent (microRNA (miRBase v20), lncRNA, mRNA, epigenetics) • Sequencing Services on Illumina (small RNA, transcriptome, exome) • High Throughput qRT-PCR (Protein Panels (Proseek® by Olink) for Cardiovascular, Inflammation, Oncology, microRNA, …)

HT VALIDATION • qRT-PCR (microRNA (miScript or TaqMan), Genexpression, Genotyping, DigitalPCR …)

BIOINFORMATICS • Proprietary Signature Discovery • Differential Expression Analysis (hierarchical clustering, heat maps, (pairwise) limma-/t-testing, AUC, PCA) • Multivariate, combined analysis of different biomarker classes (microRNA target assignment, multi-algorithm target predictions, Pathway Analyses, Gene Ontology Enrichment)

Vertrieb: Dienstleistungen (s.o)